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Nucleotide sequence coding for the “signal peptide” and N terminus of the hemagglutinin from an Asian (H2N2) strain of influenza virus

Identifieur interne : 002901 ( Main/Exploration ); précédent : 002900; suivant : 002902

Nucleotide sequence coding for the “signal peptide” and N terminus of the hemagglutinin from an Asian (H2N2) strain of influenza virus

Auteurs : Gillian M. Air [Australie]

Source :

RBID : ISTEX:828EEFEFCB772B9B5FE88F0C9B5CCE44D47681A2

Descripteurs français

English descriptors

Abstract

Abstract: The “dideoxy” sequencing method has been used to obtain 121 nucleotides of sequence of cDNA transcribed from the 3′ end of the RNA segment which contains the coding information for the hemagglutinin of influenza virus A/RI/5−/57 (H2N2). Since the viral RNA is of negative polarity, the cDNA sequence is equivalent to the region at the 5′ end of the mRNA. The first initiation codon (A-T-G) in the cDNA sequence begins 44 nucleotides from the 5′ end. It is followed by 15 triplets coding almost entirely for hydrophobic amino acids before the known amino terminal sequence of hemagglutinin from a closely related virus, A/Jap/305/57, is reached. These 15 residues presumably comprise a “signal” peptide, mediating transport through the membrane and being subsequently removed.

Url:
DOI: 10.1016/0042-6822(79)90358-1


Affiliations:


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Le document en format XML

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